HYALURONIC
ACID
WHAT IS IT?
It is an endogenous molecule, which is found in many organisms and is considered to be highly important for the evolution of species.
WHERE DOES IT COME FROM?
For many years, this polysaccharide was produced via extraction processes from tissue of animal origin. More recently, thanks to the research carried out in our laboratories, a bacteria from the Streptococcus equi family was “trained” to produce hyaluronic acid of the high standard of quality required for medical use, via a fermentation process.
The regenerative power of HYALURONIC ACID
It is well known that hyaluronic acid (HA), particularly at a high molecular weight, is very hydrophilic, contributing to its excellent skin hydrating capabilities.1 Due to its high affinity for water, HA therefore plays an integral role in maintenance and regulation of the homeostasis of intradermic water. Moreover, it has been demonstrated that HMW* HA protects cells and ECM components from free radicals’ damages.2
HA performs several biological actions in addition to being hydrophilic. These actions vary according to molecular weight.3
* High Molecular Weight
Hyaluronic acid: functions on the skin
HMW-HA
LMW-HA
HYDRATION AND BIOMECHANICAL INTEGRITY
OF THE DERMIS4
ANTI-INFLAMMATORY5
PROTECTION FROM OXIDATIVE STRESS6,7
STRUCTURAL/
PROTECTIVE
WATER BOOSTER7,8
AND ENDOGENOUS HA RESTORATION9
AND ENDOGENOUS HA RESTORATION9
HYDRATING
IMPROVEMENT OF SKIN FUNCTIONING8
PROLIFERATION/DIFFERENTIATION/ MIGRATION7,10
CELLULAR
References
1. Narurkar, Vic A et al. “Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits.” Journal of drugs in dermatology : JDD vol. 15,1 Suppl 2 (2016): s24-37.
2. Presti D, Scott JE. Cell Biochem Funct. 1994;12(4):281-288. doi:10.1002/cbf.290120409
3. Cooper CA, Brown KK, Meletis CD, Zabriskie N. Inflammation and Hyaluronic Acid. Alternative and Complementary Therapies. 2008;14(2):78-84. doi:10.1089/act.2008.14201
4. Röck, Katharina et al. Dermatology (Basel, Switzerland) vol. 221,3 (2010): 219-28. doi:10.1159/000318905
5. Albano, Giusy Daniela et al. Mediators of inflammation vol. 2016 (2016): 8727289. doi:10.1155/2016/8727289
6. Grishko, Valentina et al. Journal of Biological Chemistry 284.14 (2009): 9132–9139. doi:10.1074/jbc.M804178200
7. Pavicic, Tatjana et al. “Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment.” Journal of drugs in dermatology : JDD vol. 10,9 (2011): 990-1000.
8. Farwick, M et al. Skin pharmacology and physiology vol. 24,4 (2011): 210-7. doi:10.1159/000324296
9. Altman, R D et al. BMC musculoskeletal disorders vol. 16 321. 26 Oct. 2015, doi:10.1186/s12891-015-0775-z
10. Chistyakov, Dmitry V et al. International journal of molecular sciences vol. 20,16 3894. 9 Aug. 2019, doi:10.3390/ijms20163894
1. Narurkar, Vic A et al. “Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits.” Journal of drugs in dermatology : JDD vol. 15,1 Suppl 2 (2016): s24-37.
2. Presti D, Scott JE. Cell Biochem Funct. 1994;12(4):281-288. doi:10.1002/cbf.290120409
3. Cooper CA, Brown KK, Meletis CD, Zabriskie N. Inflammation and Hyaluronic Acid. Alternative and Complementary Therapies. 2008;14(2):78-84. doi:10.1089/act.2008.14201
4. Röck, Katharina et al. Dermatology (Basel, Switzerland) vol. 221,3 (2010): 219-28. doi:10.1159/000318905
5. Albano, Giusy Daniela et al. Mediators of inflammation vol. 2016 (2016): 8727289. doi:10.1155/2016/8727289
6. Grishko, Valentina et al. Journal of Biological Chemistry 284.14 (2009): 9132–9139. doi:10.1074/jbc.M804178200
7. Pavicic, Tatjana et al. “Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment.” Journal of drugs in dermatology : JDD vol. 10,9 (2011): 990-1000.
8. Farwick, M et al. Skin pharmacology and physiology vol. 24,4 (2011): 210-7. doi:10.1159/000324296
9. Altman, R D et al. BMC musculoskeletal disorders vol. 16 321. 26 Oct. 2015, doi:10.1186/s12891-015-0775-z
10. Chistyakov, Dmitry V et al. International journal of molecular sciences vol. 20,16 3894. 9 Aug. 2019, doi:10.3390/ijms20163894