THE DUAL POWER
OF BIOSTIMULATION AND CORRECTION
Hyal-System DUO is a hyaluronic acid hydrogel formulation based on the proprietary MU.C.H. (Multi-Crosslinked Hyaluronan)
Technology, that combines two types of HA for long-term correction and filling of medium to deep wrinkles, thereby restoring tissue
density1: 25% HA ACP and 75% HA cross-linked with BDDE. It means that Mu.C.H. technology requires 25% less BDDE with respect
to standard crosslinking2.
It improves skin firmness and elasticity, giving a rejuvenating effect to the skin8
As a result, the skin is firm, elastic and rejuvenated.
It improves skin firmness and elasticity, giving a rejuvenating effect to the skin8
As a result, the skin is firm, elastic and rejuvenated.
Composition
Hyaluronic Acid BDDE-Crosslinked 1.9%+ACP 0.6%
HA Concentration
25 mg/ml
Technology
Mu.C.H. Multi-Crosslinked Hyaluronan TechnologyÂŽ
Injection depth
Deep dermis and hypodermis
Effect
Biostimulation, filling, redensification, correction
Presentation
1×1 ml prefilled syringeâ¨
2x27G 13mm
Before & after
BIOSTIMULATION for a progressive and sustained rejuvenation from within
Biostimulation promoted by HA increases collagen/ECM in a progressive and sustained way, ensuring long-lasting aesthetic results.3
To investigate the efficacy of HA-based dual injectable (BDDE and auto-crosslinked HA) in collagen density variations, a retrospective study on 6 female patients (age range 34â56) treated in a single session, at baseline (T0), was conducted.3
To investigate the efficacy of HA-based dual injectable (BDDE and auto-crosslinked HA) in collagen density variations, a retrospective study on 6 female patients (age range 34â56) treated in a single session, at baseline (T0), was conducted.3
Adapted from Figure 1, ref 3Â Â
OCT collagen density levels at different time intervals; histograms show an increase of collagen density up to 3 months (T3) as compared to T0, after a single session of HA-based injectable, performed in a single session at T0.Â
§Data available on five out six patientsâone patient missed follow-up at 2 months (T2).Â
The term BIOSTIMULATION indicates slow and sustained neo-collagenesis and ECM deposition after intradermal injection aimed to optimize skin physiology and achieve an aesthetic improvement3,4
Subsequent sessions of HA-biostimulatory treatment progressively increase the ECM3
Expected progressive increase in ECM with subsequent sessions of crosslinked HA injections as hypothesized based on the current concept of biostimulation.  Blue arrows indicate the difference in extracellular matrix content after each session3.
Adapted from Figure 2, ref. 3
LMW-HA (200 kDa) provides a microenvironment suitable to facilitate the physiological homeostasis of ECM.5
Product line
Hyal-System
BIOSTIMULATOR
HYBRID STIMULATOR
LIP FILLER
VOLUMIZING FILLER
SKINBOOSTER
Medical devices CE 0373, Class III.
Carefully read the warnings and instructions for use.
References:
1. Alessandrini, A et al. Plastic and reconstructive surgery vol. 118,2 (2006): 341-6. doi:10.1097/01.prs.0000227686.95099.58
2. Guarise C., et al. Carbohydrate Polymers 2012;88(2): 428-438. https://doi.org/10.1016/j.carbpol.2011.12.004
3. Guida, S. et al. Journal of cosmetic dermatology vol. 23,2 (2024): 701-703. doi:10.1111/jocd.16156
4. Ceccarelli M & Curcio C. Biostimulation and Biorestructuration of the Skin, The Physiological medical Letter, Vol. 1, Jan 2010, no.2.
5. Wohlrab J, et al. J Cosmet Dermatol. 2013; 12(1):36-40.
6. Alessandrini, A et al. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology vol. 17,6 (2015): 335-42. doi:10.3109/14764172.2015.1039038
7. Sparavigna A. et al., Journal of Cosmetic Dermatology, 13 (2014): 307-314.
8. Hyal-System DUO, IFU (MDD)
1. Alessandrini, A et al. Plastic and reconstructive surgery vol. 118,2 (2006): 341-6. doi:10.1097/01.prs.0000227686.95099.58
2. Guarise C., et al. Carbohydrate Polymers 2012;88(2): 428-438. https://doi.org/10.1016/j.carbpol.2011.12.004
3. Guida, S. et al. Journal of cosmetic dermatology vol. 23,2 (2024): 701-703. doi:10.1111/jocd.16156
4. Ceccarelli M & Curcio C. Biostimulation and Biorestructuration of the Skin, The Physiological medical Letter, Vol. 1, Jan 2010, no.2.
5. Wohlrab J, et al. J Cosmet Dermatol. 2013; 12(1):36-40.
6. Alessandrini, A et al. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology vol. 17,6 (2015): 335-42. doi:10.3109/14764172.2015.1039038
7. Sparavigna A. et al., Journal of Cosmetic Dermatology, 13 (2014): 307-314.
8. Hyal-System DUO, IFU (MDD)